Journal of Advanced in Medicinal, Pharmaceutical and Biomedical Research (JAMPBR)

Abstract Neuropsychological crises such as panic attacks, anxiety, and acute emotional distress are common yet under-recognized complications among cardiac patients. These crises can significantly impact clinical outcomes, leading to delayed treatments, increased procedural risks, and reduced patient compliance. This study employed Failure Mode and Effects Analysis (FMEA) to systematically identify and prioritize psychological failure modes across the care continuum in a cardiac unit. A multidisciplinary team analyzed potential failures in screening, detection, intervention, and post-discharge follow-up, assigning Risk Priority Numbers (RPNs) based on severity, occurrence, and detection. The highest risks identified included the absence of psychological screening at admission (RPN=504), failure to detect panic attacks during procedures (RPN=378), and inadequate staff training in recognizing distress (RPN=336). The findings underscore the urgent need for integrating standardized mental health assessments, interdisciplinary communication, and emergency psychiatric protocols into cardiac care. FMEA proved to be a practical, proactive tool for elevating mental health concerns to a core safety priority. The study advocates for systemic reforms to ensure that neuropsychological well-being is embedded within routine cardiac care, ultimately enhancing patient outcomes, satisfaction, and overall safety.

Abstract The lower third of the face plays a critical role in facial harmony and aesthetic perception, often being one of the first regions to exhibit signs of aging such as volume loss, sagging skin, and reduced definition of the jawline. The "Contouring Plus" approach combines the synergistic use of Calcium Hydroxylapatite (CaHA) and Hyaluronic Acid (HA) to offer a comprehensive, minimally invasive solution for rejuvenation and contouring of this facial region. CaHA, known for its biostimulatory properties, not only provides immediate volumization but also induces neocollagenesis, leading to long-term dermal remodeling. HA fillers, on the other hand, deliver precise augmentation and hydration, particularly effective in fine contouring and surface-level corrections. This integrated technique involves strategic placement of both substances in targeted anatomical zones, enhancing mandibular angle, chin projection, and submental definition while maintaining a natural and harmonious appearance. The approach emphasizes individual assessment, customized product layering, and attention to facial dynamics, which collectively contribute to high patient satisfaction and safety. Clinical evidence demonstrates significant improvements in facial aesthetics with minimal adverse effects, making this method an ideal option for both men and women seeking facial rejuvenation without surgery. This paper reviews the anatomical rationale, product characteristics, injection techniques, and clinical outcomes associated with the Contouring Plus protocol, positioning it as an advanced standard in modern aesthetic dermatology.

Abstract Irritable Bowel Syndrome (IBS) is a prevalent functional gastrointestinal disorder characterized by abdominal pain and altered bowel habits. Recent research highlights the critical role of the gut-brain axis (GBA) in the pathophysiology of IBS, suggesting that probiotics may serve as a therapeutic avenue. This study evaluated the impact of specific probiotic strains—Lactobacillus plantarum 299v and Bifidobacterium infantis—on IBS symptoms, gut microbiota composition, immune markers, and psychological well-being over 12 weeks in a randomized, placebo-controlled trial involving 160 patients. The probiotic group showed significant reductions in IBS Symptom Severity Scores, anxiety and depression levels, and pro-inflammatory cytokines (IL-6, TNF-α), along with increased levels of the anti-inflammatory cytokine IL-10 and normalization of cortisol patterns. Microbiota analysis revealed increased beneficial bacteria and decreased Proteobacteria in the probiotic group. These results support the hypothesis that probiotics improve IBS outcomes by modulating the gut-brain axis through microbiome restoration, immunoregulation, and hypothalamic-pituitary-adrenal (HPA) axis balance. The findings encourage the use of targeted probiotic therapies as a non-pharmacological intervention in IBS management, with implications for both gastrointestinal and mental health care.

Abstract Introduction: The significance of investigating preoperative glucose-containing fluids lies in their potential to reduce postoperative nausea and vomiting—a common and debilitating complication after elective laparotomy. By attenuating the surgical stress response and improving metabolic stability, this intervention may enhance recovery, decrease opioid use, and reduce hospitalization costs. Establishing its efficacy could lead to safer, more comfortable perioperative experiences and support broader adoption of enhanced recovery protocols in major abdominal surgery.

Material and methods: This systematic review assessed the impact of preoperative glucose-containing fluids on postoperative nausea and vomiting (PONV) in adults undergoing elective laparotomy. Relevant clinical trials and observational studies were identified through comprehensive database searches, screened, and evaluated using standardized tools. Data on PONV incidence and severity were extracted and synthesized. Heterogeneity and risk of bias were systematically assessed, supporting an evidence-based evaluation of glucose supplementation's role in enhancing postoperative recovery outcomes.

Results: This systematic review included three randomized controlled trials evaluating preoperative glucose-containing fluids in elective laparotomy. Compared to controls, glucose administration significantly reduced the incidence and severity of postoperative nausea and vomiting (PONV) and lowered antiemetic usage. These findings suggest a potential benefit of preoperative glucose loading in enhancing postoperative recovery by minimizing PONV, supporting its role as a simple, non-invasive intervention in perioperative care.

Conclusion: Preoperative administration of glucose-containing fluids significantly reduces the incidence and severity of postoperative nausea and vomiting (PONV) in patients undergoing elective laparotomy. Additionally, it decreases the need for postoperative antiemetic medications.